The Second Battle of Lepanto, also known as the Battle of Modon happened in 1500, as part of the 1499-1503 Turkish-Venetian Wars between the Ottoman Empire and the Venetians. The Ottomans, who had won the First Battle of Lepanto the previous year, were again victorious under Admiral Kemal Re'is .

Lepanto was also the scene of battles in the previous year, in 1571 see Battle of Lepanto, and in 429 BC see Battle of Naupactus.