Boutros Ghali (1846 - February 20, 1910) was a Coptic Prime Minister of Egypt from 1908 to 1910.

He was accused of favouring the British in the Denshway incident and on February 20, 1910, Ghali was assassinated by Ibrahim Nassif al-Wardani, a young pharmacology graduate who had just returned from the United Kingdom.

His grandson Boutros Boutros-Ghali, who was named after him, would go on to become the Deputy Prime Minister of Egypt and a Secretary-General of the United Nations.