In Greek mythology, Clymene or Klymenê ("famous might") is the name of at least six possibly distinct females.

• An Oceanid also called Asia, the wife of Iapetus. Mother of Atlas, Epimetheus, Prometheus, and Menoetius.
• An Oceanid, mother of Phaethon by Helios, sometimes as a full wife and mother also of the Heliades (essentially equated with Rhode) and sometimes as wife of Merops with whom Helios secretly lay.
• Mother of Deucalion by Prometheus. Possibly one of the above two (parent-child couplings occasionally occur among the earliest deities in Greek myth).
• Wife of Merops and Queen of Ethiopia, mother of Pandareus, possibly the same as the previous.
• Mother of Atalanta and wife of Schoeneus or Iasus.
• Grandaughter of Minos and mother of Palamedes by Nauplius.
• By Ares, mother of Diomedes

104 Klymene is an asteroid.