See Mission Hills for other places of the same name.

Mission Hills is a suburban community of Los Angeles, California. It is located in the San Fernando Valley, around the northern junction of Interstate 5 and Interstate 405.

The community is notable as the location of the California mission Mission San Fernando Rey de Espana. The Andres Pico Adobe, second oldest residence still standing in Los Angeles is also here. The San Fernando Mission Cemetery is still actively used.