The New Road from Paddington to Islington was constructed in the 1740s to relieve congestion in the built up area of London, England. At that time the districts of Marylebone, Fitzrovia and Bloomsbury were on the northern edge of the city, and only the southern parts of them had been built up.

The road is now widely regarded as being in central London, and it is one of the busiest main roads in the city. It runs from Edgware Road near Paddington Station in the west The Angel, Islington, in the East. It is classified as the A501 . The western section between Edgware Road and Park Square is known as Marylebone Road, the central section between Park Square and Kings Cross is known as Euston Road, and the eastern section from Kings Cross to The Angel, Islington, is called Pentonville Road.

City Road was constructed soon after the New Road to continue the route to the northern edge of the City of London.