Saint-Simon can refer to various people:

• Claude de Rouvroy, duc de Saint-Simon (1607–1693), French courtier
• Louis de Rouvroy, duc de Saint-Simon (1675–1755), French soldier, diplomatist and writer of memoirs
• Claude Henri de Rouvroy, Comte de Saint-Simon (1760–1825), the founder of French socialism

• Simon the Canaanite

• Saint-Simon (1884–1908), British racehorse.

Saint-Simon is also the name or part of the name of several communes in France:

• Saint-Simon , in the Aisne département
• Saint-Simon , in the Cantal département
• Saint-Simon , in the Charente département
• Saint-Simon , in the Lot département

• Saint-Simon-de-Bordes , in the Charente-Maritime département
• Saint-Simon-de-Pellouaille , in the Charente-Maritime département