Sir Henry Holland, 1st Baronet (27 October 1788-27 October 1873) was a British physician and travel writer.

Holland was a cousin of the novelist Elizabeth Gaskell and nephew of Josiah Wedgwood. He married, in 1822, M Caldwell, with whom he had two sons and two daughters, including Henry Holland, 1st Viscount Knutsford. He later became son-in-law to the wit Sydney Smith whose daughter, Saba, he married as his second wife, with whom he had three daughters.

Holland, son of the physician Peter Holland, gained fame through his travel writings, having travelled to Iceland and through the Balkans and the Iberian peninsula, while the British were at war with France. He was also a talented society physician, and between his good looks, his charm, and his experiences and conversation, he was much in demand.

Holland died on his 85th birthday in 1873.

Among Holland's descendants are Sydney Buxton, 1st Earl Buxton, and the latter's grandson, the present Duke of Grafton.