United States Highway 281 is a north-south United States highway.

Termini

The highway's northern terminus is at the International Peace Garden, north of Dunseith, North Dakota at the Canadian border, where it continues as Manitoba Provincial Highway 10. The route between Dunseith and the border is shared with North Dakota Highway 3 . The southern terminus of US 281 is in Brownsville, Texas, just short of the Mexican border.

States Traversed

The highway passes through the following states:

• North Dakota
• South Dakota
• Nebraska
• Kansas
• Oklahoma
• Texas

Major Cities

Major cities along the route include:

• Jamestown, North Dakota
• Aberdeen, South Dakota
• Grand Island, Nebraska
• Dodge City, Kansas
• Lawton, Oklahoma
• Wichita Falls, Texas
• San Antonio, Texas
• Brownsville, Texas

Intersections

US 281 Intersects with the following Interstate Highways:

• Interstate 94 in Jamestown, North Dakota
• Interstate 90 near Plankinton, South Dakota
• Interstate 80 in Grand Island, Nebraska
• Interstate 70 in Russell, Kansas
• Interstate 40 in Hinton, Oklahoma
• Interstates 10, 410, 35, and 37 in San Antonio, Texas
• Interstate 37 between Pleasanton and Three Rivers, Texas (shared route)

Related US Routes

• U.S. Highway 81
• U.S. Highway 181
• List of U.S. Highways