VME (Virtual Machine Environment) is a mainframe operating system developed by the UK company International Computers Ltd (ICL). Originally developed in the 1970s to drive ICL's (then) new 2900 series mainframes, the operating system is now known as OpenVME, and runs on ICL Series 39 and Trimetra mainframe computers.

ICL itself has been absorbed into the Fujitsu group.

VME is also an often-used short form for the VMEbus computer bus.